Low Pessimism Protects Against Stroke

Low pessimism protects against stroke: The HeSSup prospective cohort study

Background and Purpose: The association between optimism and pessimism and health outcomes has attracted increasing research interest. To date, the association between these psychological variables and risk of stroke remains unclear. We examined the relationship between pessimism and the 7-year incidence of stroke. Methods: A random sample of 23 216 adults (9 480 men, 13 796 women) aged 20-54 y...

Low pessimism protects against stroke: the Health and Social Support (HeSSup) prospective cohort study.

BACKGROUND AND PURPOSE The association between optimism and pessimism and health outcomes has attracted increasing research interest. To date, the association between these psychological variables and risk of stroke remains unclear. We examined the relationship between pessimism and the 7-year incidence of stroke. METHODS A random sample of 23 216 adults (9480 men, 13 796 women) aged 20 to 54...

Against Pessimism in Tuberculosis

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

Stroke is the most common type of cerebrovascular disease and is a leading cause of disability and death. Ischemic stroke accounts for approximately 80% of all strokes. The remaining 20% of strokes are hemorrhagic in nature. To date, therapeutic options for acute ischemic stroke are very limited. Recent research suggests that shifting microglial phenotype from the pro-inflammatory M1 state towa...

Vascular PPARδ protects against stroke-induced brain injury.

OBJECTIVE To investigate the effects of peroxisome proliferator-activated receptor (PPAR)δ in the cerebral vasculature following stroke-induced brain injury. METHODS AND RESULTS Here, we report a novel finding that selective PPARδ genetic deletion in vascular smooth muscle cells (VSMCs) resulted in increased cerebrovascular permeability and brain infarction in mice after middle cerebral arter...